Article
Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy.
Molecular medicine reports - 1 Sept 2015
Qu Xin-Kai, Yuan Fang, Li Ruo-Gu, Xu Lei, Jing Wei-Feng, Liu Hua, Xu Ying-Jia, Zhang Min, Liu Xu, Fang Wei-Yi, Yang Yi-Qing, Qiu Xing-Biao
Abstract excerpt
Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disease. It is the most common cause of chronic congestive heart failure and the most frequent reason for heart transplantation in young adults. There is increasing evidence demonstrating that genetic defects are involved in the pathogenesis of idiopathic DCM. Recent studies have shown that genetically defective LRRC10 predisposes animals...
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