Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.

Nature communications - 16 Dec 2019

Mitchell Khadijah A, Nichols Noah, Tang Wei, Walling Jennifer, Stevenson Holly, Pineda Marbin, Stefanescu Roxana, Edelman Daniel C, Girvin Andrew T, Zingone Adriana, Sinha Sanju, Bowman Elise, Rossi Emily L, Arauz Rony F, Jack Zhu Yuelin, Lack Justin, Weingartner Elizabeth, Waterfall Joshua J, Pine Sharon R, Simmons John, Meltzer Paul, Ryan Bríd M

Abstract excerpt

Reducing or eliminating persistent disparities in lung cancer incidence and survival has been challenging because our current understanding of lung cancer biology is derived primarily from populations of European descent. Here we show results from a targeted sequencing panel using NCI-MD Case Control Study patient samples and reveal a significantly higher prevalence of PTPRT and JAK2 mutations in lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Health Status Disparities

Share to Interleukin-6

Share to Janus Kinase 2

Share to MicroRNAs

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 31844068
DOI: 10.1038/s41467-019-13732-y
PMCID: PMC6915783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.PMID 31844068Read ↗

Whole-Exome Profiling of NSCLC Among African Americans.Semantic proximity Read ↗

Genomic Characterization of Non–Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel SequencingSemantic proximity Read ↗

Genomic landscape of lung adenocarcinomas in different racesSemantic proximity Read ↗

Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center.Semantic proximity Read ↗

The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2).Semantic proximity Read ↗

Somatic mutations affect key pathways in lung adenocarcinoma.Semantic proximity Read ↗

Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy.Semantic proximity Read ↗

Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation ConsortiumSemantic proximity Read ↗

Molecular co-alteration patterns of RICTOR-mutant metastatic lung adenocarcinomas: a single-center cohort study.Semantic proximity Read ↗

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation.Semantic proximity Read ↗

Prognostic significance of RICTOR mutations in EGFR-mutant metastatic lung adenocarcinoma: a retrospective cohort study.Semantic proximity Read ↗

Genetic Ancestry and Somatic Mutations in Lung Adenocarcinoma: Insights from Real-World Clinico-Genomic DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.