Article
Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.
Scientific reports - 22 May 2015
Xiao Chuan-Xing, Xiao Jing-Jing, Xu Hong-Zhi, Wang Huan-Huan, Chen Xu, Liu Yuan-Sheng, Li Ping, Shi Ying, Nie Yong-Zhan, Li Shao, Wu Kai-Chun, Liu Zhan-Ju, Ren Jian-Lin, Guleng Bayasi
Abstract excerpt
Previous studies have highlighted the role of genetic predispositions in disease, and several genes had been identified as important in Crohn's disease (CD). However, many of these genes are likely rare and not associated with susceptibility in Chinese CD patients. We found 294 shared identical variants in the CD patients of which 26 were validated by Sanger sequencing. Two heterozygous IFN variants (IFNA10 c.60...
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