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Article

Negative biomarker based male fertility evaluation: Sperm phenotypes associated with molecular-level anomalies.

Asian journal of andrology - 1 Jan 2000

Sutovsky Peter, Aarabi Mahmoud, Miranda-Vizuete Antonio, Oko Richard

Abstract excerpt

Biomarker-based sperm analysis elevates the treatment of human infertility and ameliorates reproductive performance in livestock. The negative biomarker-based approach focuses on proteins and ligands unique to defective spermatozoa, regardless of their morphological phenotype, lending itself to analysis by flow cytometry (FC). A prime example is the spermatid specific thioredoxin SPTRX3/TXNDC8, retained in the...

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Identifiers

PMID: 25999356
DOI: 10.4103/1008-682X.153847
PMCID: PMC4492044

Genes

TXNDC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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