Article
Generation of Donor-specific T Regulatory Type 1 Cells From Patients on Dialysis for Cell Therapy After Kidney Transplantation.
Transplantation - 1 Aug 2015
Petrelli Alessandra, Tresoldi Eleonora, Mfarrej Bechara G, Paganelli Alessia, Spotti Donatella, Caldara Rossana, Secchi Antonio, Battaglia Manuela
Abstract excerpt
BACKGROUND: T regulatory type 1 (Tr1) cell-mediated induction of tolerance in preclinical models of transplantation is remarkably effective. The clinical application of such a therapy in patients on dialysis undergoing kidney transplantation should take into account the possible alterations of the immune system observed in these patients. Herein, we aimed at testing the ability to generate donor-specific Tr1...
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