Article
Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers.
Scientific reports - 18 May 2015
Jang Jin Sung, Lee Adam, Li Jun, Liyanage Hema, Yang Yanan, Guo Lixia, Asmann Yan W, Li Peter W, Erickson-Johnson Michele, Sakai Yuta, Sun ZhiFu, Jeon Hyo-Sung, Hwang Hayoung, Bungum Aaron O, Edell Eric S, Simon Vernadette A, Kopp Karla J, Eckloff Bruce, Oliveira Andre M, Wieben Eric, Aubry Marie Christine, Yi Eunhee, Wigle Dennis, Diasio Robert B, Yang Ping, Jen Jin
Abstract excerpt
Lung adenocarcinomas from never smokers account for approximately 15 to 20% of all lung cancers and these tumors often carry genetic alterations that are responsive to targeted therapy. Here we examined mutation status in 10 oncogenes among 89 lung adenocarcinomas from never smokers. We also screened for oncogene fusion transcripts in 20 of the 89 tumors by RNA-Seq. In total, 62 tumors had mutations in at least...
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