Article
Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.
The Journal of nutrition - 1 Jul 2015
Carter Tonia C, Pangilinan Faith, Molloy Anne M, Fan Ruzong, Wang Yifan, Shane Barry, Gibney Eileen R, Midttun Øivind, Ueland Per M, Cropp Cheryl D, Kim Yoonhee, Wilson Alexander F, Bailey-Wilson Joan E, Brody Lawrence C, Mills James L
Abstract excerpt
BACKGROUND: Vitamin B-6 interconversion enzymes are important for supplying pyridoxal 5'-phosphate (PLP), the co-enzyme form, to tissues. Variants in the genes for these enzymes [tissue nonspecific alkaline phosphatase (ALPL), pyridoxamine 5'-phosphate oxidase, pyridoxal kinase, and pyridoxal phosphatase] could affect enzyme function and vitamin B-6 status. OBJECTIVES: We tested whether single-nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.