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Article

Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study.

Journal of human genetics - 1 Mar 2020

Nagata Miho, Setoh Kazuya, Takahashi Meiko, Higasa Koichiro, Kawaguchi Takahisa, Kawasaki Hidenori, Wada Takahito, Watanabe Atsushi, Sawai Hideaki, Tabara Yasuharu, Yamada Takahiro, Matsuda Fumihiko, Kosugi Shinji

Abstract excerpt

Although alkaline phosphatase (ALP) activity is relatively low in carriers of recessive type hypophosphatasia (HPP), most are asymptomatic and therefore do not undergo medical evaluations. We analyzed the association of ALP-encoding ALPL variants with serum ALP and bone traits in the general Japanese population. Study participants (n = 9671) were from the Nagahama Study, which was a longitudinal cohort study of...

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PMID: 31857675
DOI: 10.1038/s10038-019-0712-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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