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Article

The spatial profiles and metabolic capabilities of microbial populations impact the growth of antibiotic-resistant mutants.

Journal of the Royal Society, Interface - 6 Jun 2015

Kaushik Karishma S, Ratnayeke Nalin, Katira Parag, Gordon Vernita D

Abstract excerpt

Antibiotic resistance adversely affects clinical and public health on a global scale. Using the opportunistic human pathogen Pseudomonas aeruginosa, we show that increasing the number density of bacteria, on agar containing aminoglycoside antibiotics, can non-monotonically impact the survival of antibiotic-resistant mutants. Notably, at high cell densities, mutant survival is inhibited. A wide range of bacterial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25972434
DOI: 10.1098/rsif.2015.0018
PMCID: PMC4590495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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