Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Searching for the human genetic factors standing in the way of universally effective vaccines.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2015

Mentzer Alexander J, O'Connor Daniel, Pollard Andrew J, Hill Adrian V S

Abstract excerpt

Vaccines have revolutionized modern public health. The effectiveness of some vaccines is limited by the variation in response observed between individuals and across populations. There is compelling evidence that a significant proportion of this variability can be attributed to human genetic variation, especially for those vaccines administered in early life. Identifying and understanding the determinants of this...

Topics

Antibody Formation
Communicable Diseases
Genetic Variation
Genome-Wide Association Study
Humans
Vaccines

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25964463
DOI: 10.1098/rstb.2014.0341
PMCID: PMC4527396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Searching for the human genetic factors standing in the way of universally effective vaccines.PMID 25964463Read ↗

Application of pharmacogenomics to vaccines.Semantic proximity Read ↗

Genetic variation in the response to vaccination.Semantic proximity Read ↗

Genetics and Vaccines in the Era of Personalized MedicineSemantic proximity Read ↗

Host genetic factors in hepatitis B infection, liver cancer and vaccination response: a review with a focus on Africa.Semantic proximity Read ↗

Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics.Semantic proximity Read ↗

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccinesSemantic proximity Read ↗

The link between genetic variation and variability in vaccine responses: systematic review and meta-analyses.Semantic proximity Read ↗

Human genetics of responses to vaccinesSemantic proximity Read ↗

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Semantic proximity Read ↗

Human genetics of susceptibility to live-attenuated viral vaccines.Semantic proximity Read ↗

Vaccinomics: current findings, challenges and novel approaches for vaccine development.Semantic proximity Read ↗

The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.