Article
MicroRNA-122 associates with serum apolipoprotein B but not liver fibrosis markers in CHC genotype 1 infection.
Journal of medical virology - 1 Oct 2015
Lee Tzu-Hao, Matta Bassem, King Bernard D, Hodges Michael R, Tillmann Hans L, Patel Keyur
Abstract excerpt
miR-122 is the predominant liver miRNA that regulates hepatic lipid metabolism and inflammation. Hepatitis C virus (HCV) modulates host intracellular lipid metabolism. HCV stability and propagation also depend on an interaction between virus and miR-122. Our aims were to examine the associations between miR-122, apolipoproteins, and serum makers of fibrosis in chronic hepatitis C (CHC) patients. We evaluated...
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