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Article

New monogenic autoinflammatory diseases--a clinical overview.

Seminars in immunopathology - 1 Jul 2015

Canna Scott W, Goldbach-Mansky Raphaela

Abstract excerpt

Translating pathogenic insights gained from monogenic defects that cause autoinflammatory diseases into novel therapies has dramatically improved the lives of patients with these syndromes. The last 15 years have focused on the central role of IL-1 in driving autoinflammatory phenotypes and on therapies blocking IL-1 signaling. Recent discoveries from patients unresponsive to IL-1 blockade have highlighted other...

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Identifiers

PMID: 25963521
DOI: 10.1007/s00281-015-0493-5
PMCID: PMC4556430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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