Article
Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.
Nature reviews. Rheumatology - 1 Jul 2021
Aksentijevich Ivona, Schnappauf Oskar
Abstract excerpt
Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by dysregulation in the innate immune system. The molecular mechanisms of these disorders are linked to defects in inflammasome-mediated, NF-κB-mediated or interferon-mediated inflammatory signalling pathways, cytokine receptors, the actin cytoskeleton, proteasome complexes and various enzymes. As with other human disorders,...
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