Article
The landscape of genomic imprinting across diverse adult human tissues.
Genome research - 1 Jul 2015
Baran Yael, Subramaniam Meena, Biton Anne, Tukiainen Taru, Tsang Emily K, Rivas Manuel A, Pirinen Matti, Gutierrez-Arcelus Maria, Smith Kevin S, Kukurba Kim R, Zhang Rui, Eng Celeste, Torgerson Dara G, Urbanek Cydney, Li Jin Billy, Rodriguez-Santana Jose R, Burchard Esteban G, Seibold Max A, MacArthur Daniel G, Montgomery Stephen B, Zaitlen Noah A, Lappalainen Tuuli
Abstract excerpt
Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously...
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