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Article

Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels.

Circulation research - 8 May 2015

Li Jun, Xie Duanyang, Huang Jian, Lv Fei, Shi Dan, Liu Yi, Lin Li, Geng Li, Wu Yufei, Liang Dandan, Chen Yi-Han

Abstract excerpt

RATIONALE: Cold-inducible RNA-binding protein (CIRP) is constitutively expressed at low levels across various tissues. It is rapidly upregulated by multiple stresses, underlying a general role for CIRP in organic adaptations to pathophysiological conditions. However, the role of CIRP in the heart remains unclear. OBJECTIVE: To examine the biofunctions of CIRP in the mammalian heart. METHODS AND RESULTS: Rats with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25953924
DOI: 10.1161/CIRCRESAHA.116.306287

Genes

KCND2
KCND3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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