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Autophagy in cellular metabolism and cancer

1 Jan 2015

Abstract excerpt

Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient signaling through...

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PMID: 25654550
DOI: 10.1172/jci73942

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