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Article

Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

Journal of psychopharmacology (Oxford, England) - 1 Aug 2015

Athanasiu Lavinia, Smorr Lisa-Lena H, Tesli Martin, Røssberg Jan I, Sønderby Ida E, Spigset Olav, Djurovic Srdjan, Andreassen Ole A

Abstract excerpt

Individual variation in pharmacokinetics of psychotropic drugs, particularly metabolism, is an important factor to consider in pharmacological treatment in psychiatry. A large proportion of this variance is still not accounted for, but evidence so far suggests the involvement of genetic factors. We performed a genome-wide association study (GWAS) with concentration dose ratio (CDR) as sub-phenotype to assess...

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PMID: 25944848
DOI: 10.1177/0269881115584469

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