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Article

Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma

6 May 2015

Abstract excerpt

Measuring concentrations of the differentiation-promoting hormone retinoic acid (RA) in glioblastoma tissues would help to understand the reason why RA treatment has been inefficient in clinical trials involving brain tumor patients. Here, we apply a recently established extraction and measurement protocol to screen glioblastoma tissues for the levels of the RA precursor retinol and biologically active RA....

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PMID: 25944104
DOI: 10.1002/glia.22849

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