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Article

Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

5 May 2015

Abstract excerpt

In animal models, prenatal and postnatal stress is associated with elevated hypothalamic-pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we...

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PMID: 25942041
DOI: 10.1038/tp.2014.140

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