Article
Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study.
Developmental psychobiology - 1 Nov 2023
Zusman Enav Z, Chau Cecil M Y, Bone Jeffrey N, Hookenson Kaia, Brain Ursula, Glier Melissa B, Grunau Ruth E, Weinberg Joanne, Devlin Angela M, Oberlander Tim F
Abstract excerpt
Prenatal exposure to maternal depression and serotonin reuptake inhibitor (SRI) antidepressants both affect the development of the hypothalamic-pituitary-adrenal (HPA) system, possibly via the neurotransmitter serotonin (5HT). In a community cohort, we investigated the impact of two factors that shape prenatal 5HT signaling (prenatal SRI [pSRI] exposure and child SLC6A4 genotype) on HPA activity at age 6 years....
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