Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.

Investigative ophthalmology & visual science - 1 Mar 2001

Libby R T, Steel K P

Abstract excerpt

PURPOSE: In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dark Adaptation
Share to Deafness
Share to Dyneins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroretinography

Share to Mice, Inbred CBA

Share to Myosin VIIa

Share to Myosins

Share to Retinal Degeneration

Source

Identifiers

PMID: 11222540

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11222540-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.PMID 11222540Read ↗

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat.Semantic proximity Read ↗

Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells.Semantic proximity Read ↗

Retinal disease course in Usher syndrome 1B due to MYO7A mutations.Semantic proximity Read ↗

Mouse models for Usher syndrome 1B.Semantic proximity Read ↗

Assessment of retinal structure and function in Ames waltzer mice.Semantic proximity Read ↗

Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapy.Semantic proximity Read ↗

Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.Semantic proximity Read ↗

The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65Semantic proximity Read ↗

Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence.Semantic proximity Read ↗

Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.Semantic proximity Read ↗

CLINICAL PRESENTATION AND DISEASE COURSE OF USHER SYNDROME BECAUSE OF MUTATIONS IN MYO7A OR USH2A.Semantic proximity Read ↗

Genotype-phenotype correlation in patients with Usher syndrome and pathogenic variants in MYO7A: implications for future clinical trials.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.