Article
An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O157.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2015
Shimizu Takeshi, Hirai Shinichiro, Yokoyama Eiji, Ichimura Kimitoshi, Noda Masatoshi
Abstract excerpt
A novel virulence gene, norV, that encodes nitric oxide (NO) reductase, was examined to investigate the emergence of enterohemorrhagic Escherichia coli (EHEC) O157 subgroup C clusters 2 and 3 from subgroup C cluster 1. Deletion of norV occurred at a point between cluster 1 and cluster 2 just after or at the same time that an stx2 bacteriophage, which retains Shiga toxin 2 gene, was inserted into wrbA, which...
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