Article
Epstein-Barr virus genetic variation in lymphoblastoid cell lines derived from Kenyan pediatric population.
PloS one - 1 Jan 2015
Simbiri Kenneth O, Smith Nicholas A, Otieno Richard, Wohlford Eric E M, Daud Ibrahim I, Odada Sumba P, Middleton Frank, Rochford Rosemary
Abstract excerpt
Epstein-Barr virus (EBV) is associated with Burkitt's lymphoma (BL), and in regions of sub-Saharan Africa where endemic BL is common, both the EBV Type 1 (EBV-1) and EBV Type 2 strains (EBV-2) are found. Little is known about genetic variation of EBV strains in areas of sub-Saharan Africa. In the present study, spontaneous lymphoblastoid cell lines (LCLs) were generated from samples obtained from Kenya....
Topics
- Burkitt Lymphoma
- Cell Line
- Child
- Epstein-Barr Virus Infections
- Epstein-Barr Virus Nuclear Antigens
- Founder Effect
- Gene Expression
- Genetic Variation
- Genome, Viral
- Herpesvirus 4, Human
- High-Throughput Nucleotide Sequencing
- Humans
- Kenya