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Article

TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge.

Archives of gynecology and obstetrics - 1 Jun 2021

Grill Sabine, Ramser Juliane, Hellebrand Heide, Pfarr Nicole, Boxberg Melanie, Brambs Christine, Ditsch Nina, Meindl Alfons, Groß Eva, Meitinger Thomas, Kiechle Marion, Quante Anne S

Abstract excerpt

PURPOSE: TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high-risk surveillance program is implemented, which evokes substantial psychological discomfort. Emphasizing the lack...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33245408
DOI: 10.1007/s00404-020-05883-x
PMCID: PMC8087555

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