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The Differential Effects of Anti-Diabetic Thiazolidinedione on Prostate Cancer Progression Are Linked to the TR4 Nuclear Receptor Expression Status.

Neoplasia (New York, N.Y.) - 1 Apr 2015

Lin Shin-Jen, Lin Chang-Yi, Yang Dong-Rong, Izumi Kouji, Yan Emily, Niu Xiaodan, Chang Hong-Chiang, Miyamoto Hiroshi, Wang Nancy, Li Gonghui, Chang Chawnshang

Abstract excerpt

The insulin sensitizers, thiazolidinediones (TZDs), have been used as anti-diabetic drugs since the discovery of their ability to alter insulin resistance through transactivation of peroxisome proliferator-activated receptors (PPARs). However, their side effects in hepatitis, cardiovascular diseases, and bladder cancer resulted in some selling restrictions in the USA and Europe. Here, we found that the potential...

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Identifiers

PMID: 25925376
DOI: 10.1016/j.neo.2015.02.005
PMCID: PMC4415117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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