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Article

Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolon.

Journal of gastroenterology - 1 Jan 2008

Adachi Yasushi, Ishii Yoshifumi, Yoshimoto Mitsuru, Yoshida Yukinari, Endo Takao, Yamamoto Hiroyuki, Akashi Hirofumi, Imai Kohzoh, Shinomura Yasuhisa, Kato Yasuo

Abstract excerpt

BACKGROUND: Interstitial cells of Cajal (ICCs) are detected as a pacemaker of gastrointestinal movement and express c-kit and CD34. Recently, ICCs have implicated pathogenesis in several human diseases presenting gastrointestinal motor dysfunction. This study was performed to clarify the role of ICCs in idiopathic sigmoid megacolon using histological and immunohistochemical examinations. METHODS: Four adult...

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Identifiers

PMID: 18709485
DOI: 10.1007/s00535-008-2207-4

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