Article
Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.
BMC biology - 17 Apr 2015
Venkatraman Girija Umakhanth, Furze Christopher M, Gingras Alexandre R, Yoshizaki Takayuki, Ohtani Katsuki, Marshall Jamie E, Wallis A Katrine, Schwaeble Wilhelm J, El-Mezgueldi Mohammed, Mitchell Daniel A, Moody Peter C E, Wakamiya Nobutaka, Wallis Russell
Abstract excerpt
BACKGROUND: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its associated serine protease MASP-3 serves as a guidance cue for neural crest development. High serum levels are associated with disseminated intravascular...
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