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Article

The Influence of Known Genetic Variants on Subclinical Cardiovascular Outcomes in Childhood: Generation R Study.

Circulation. Cardiovascular genetics - 1 Aug 2015

Punwasi Rani V G, Monnereau Claire, Hofman Albert, Jaddoe Vincent W V, Felix Janine F

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) for subclinical cardiovascular outcomes in adults. We examined the influence of these variants on the same outcomes in childhood. METHODS AND RESULTS: In a population-based prospective cohort study among 4137 children, we examined the associations of SNPs, individually and incorporated in genetic risk scores, which...

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PMID: 25911650
DOI: 10.1161/CIRCGENETICS.114.000915

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