Article
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.
Chemistry & biology - 23 Apr 2015
Young David C, Layre Emilie, Pan Shih-Jung, Tapley Asa, Adamson John, Seshadri Chetan, Wu Zhongtao, Buter Jeffrey, Minnaard Adriaan J, Coscolla Mireia, Gagneux Sebastien, Copin Richard, Ernst Joel D, Bishai William R, Snider Barry B, Moody D Branch
Abstract excerpt
Although small molecules shed from pathogens are widely used to diagnose infection, such tests have not been widely implemented for tuberculosis. Here we show that the recently identified compound, 1-tuberculosinyladenosine (1-TbAd), accumulates to comprise >1% of all Mycobacterium tuberculosis lipid. In vitro and in vivo, two isomers of TbAd were detected that might serve as infection markers. Using mass...
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