Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling cancer processes with CRISPR-Cas9.

Trends in biotechnology - 1 Jun 2015

Lu Xiao-Jie, Qi Xiaolong, Zheng Dong-Hui, Ji Li-Juan

Abstract excerpt

CRISPR-Cas9 is an RNA-guided site-specific DNA editing tool which, together with its reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of desired combinations of cancer-associated genomic and/or epigenetic aberrations simultaneously or sequentially, thus facilitating massive functional interrogations and therapy testing.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to CRISPR-Cas Systems
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to RNA Editing

Source

Identifiers

PMID: 25908505
DOI: 10.1016/j.tibtech.2015.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling cancer processes with CRISPR-Cas9.PMID 25908505Read ↗

CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies.Semantic proximity Read ↗

CRISPR/Cas9 editing of the genome for cancer modeling.Semantic proximity Read ↗

CRISPR/Cas9 for Cancer Therapy: Hopes and ChallengesSemantic proximity Read ↗

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modelingSemantic proximity Read ↗

Precision Oncology in the CRISPR Era: Applications and Future Horizons in Cancer TherapySemantic proximity Read ↗

Precision Oncology in the CRISPR Era: Applications and Future Horizons in Cancer TherapySemantic proximity Read ↗

Characterizing genes associated with cancer using the CRISPR/Cas9 system: A systematic review of genes and methodological approaches.Semantic proximity Read ↗

Using CRISPR to understand how cancer mutations happen.Semantic proximity Read ↗

CRISPR/Cas9 Genome Editing in Oncology: Mechanisms, Therapeutic Platforms and Translational ChallengesSemantic proximity Read ↗

From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision OncologySemantic proximity Read ↗

From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision OncologySemantic proximity Read ↗

CRISPR/Cas mediated epigenome editing for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.