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Article

Purifying selection can obscure the ancient age of viral lineages.

Molecular biology and evolution - 1 Dec 2011

Wertheim Joel O, Kosakovsky Pond Sergei L

Abstract excerpt

Statistical methods for molecular dating of viral origins have been used extensively to infer the time of most common recent ancestor for many rapidly evolving pathogens. However, there are a number of cases, in which epidemiological, historical, or genomic evidence suggests much older viral origins than those obtained via molecular dating. We demonstrate how pervasive purifying selection can mask the ancient...

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Identifiers

PMID: 21705379
DOI: 10.1093/molbev/msr170
PMCID: PMC3247791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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