Article
Bicluster Sampled Coherence Metric (BSCM) provides an accurate environmental context for phenotype predictions.
BMC systems biology - 1 Jan 2015
Danziger Samuel A, Reiss David J, Ratushny Alexander V, Smith Jennifer J, Plaisier Christopher L, Aitchison John D, Baliga Nitin S
Abstract excerpt
BACKGROUND: Biclustering is a popular method for identifying under which experimental conditions biological signatures are co-expressed. However, the general biclustering problem is NP-hard, offering room to focus algorithms on specific biological tasks. We hypothesize that conditional co-regulation of genes is a key factor in determining cell phenotype and that accurately segregating conditions in biclusters...
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