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Article

Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing.

BMC cancer - 12 Feb 2015

Cavelier Lucia, Ameur Adam, Häggqvist Susana, Höijer Ida, Cahill Nicola, Olsson-Strömberg Ulla, Hermanson Monica

Abstract excerpt

BACKGROUND: The evolution of mutations in the BCR-ABL1 fusion gene transcript renders CML patients resistant to tyrosine kinase inhibitor (TKI) based therapy. Thus screening for BCR-ABL1 mutations is recommended particularly in patients experiencing poor response to treatment. Herein we describe a novel approach for the detection and surveillance of BCR-ABL1 mutations in CML patients. METHODS: To detect mutations...

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Topics

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Share to Alternative Splicing
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Fusion Proteins, bcr-abl

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to RNA Isoforms

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 25880391
DOI: 10.1186/s12885-015-1046-y
PMCID: PMC4335374

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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