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Article

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2018

Schmitt Michael W, Pritchard Justin R, Leighow Scott M, Aminov Bella I, Beppu Lan, Kim Daniel S, Hodgson J Graeme, Rivera Victor M, Loeb Lawrence A, Radich Jerald P

Abstract excerpt

Purpose: Sequential treatment with targeted therapies can result in complex combinations of resistance mutations in drug targets. This mutational complexity has spurred the development of pan-target inhibitors, i.e., therapies for which no single target mutation can cause resistance. Because the propensity for on- versus off-target resistance varies across cancer types, a deeper understanding of the mutational...

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Share to Clonal Evolution
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Philadelphia Chromosome

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 30042204
DOI: 10.1158/1078-0432.CCR-18-0167
PMCID: PMC6214777

Genes

ABL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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