Article
Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors.
International journal of laboratory hematology - 1 Jun 2011
Ma W, Giles F, Zhang X, Wang X, Zhang Z, Lee T-S, Yeh C-H, Albitar M
Abstract excerpt
INTRODUCTION: Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS). We report three novel alternative splicing mutants expressed as the dominant transcripts in patient with chronic myelogenous leukemia and resistance to kinase inhibitors. METHODS: We screened RNA from more than 200...
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