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Article

LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer.

Oncotarget - 10 May 2015

Shi Sheng-Jia, Wang Li-Juan, Yu Bo, Li Yun-Hui, Jin Yong, Bai Xiao-Zhong

Abstract excerpt

Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and the role of TGF-β-induced epithelial-mesenchymal transition (EMT) in trastuzumab resistance is well established, but the involvement of lncRNAs in trastuzumab resistance is still unknown. Here, we generated trastuzumab-resistant breast cancer cells with increased invasiveness compared with parental cells, and observed robust...

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Share to Epithelial-Mesenchymal Transition
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Transforming Growth Factor beta

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Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 25871474
DOI: 10.18632/oncotarget.3457
PMCID: PMC4484483

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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