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Article

Additive Genetic Effects on Circulating Periostin Contribute to the Heritability of Bone Microstructure

13 Apr 2015

Abstract excerpt

CONTEXT: Genetic factors account for 60-80% of the areal bone mineral density (aBMD) variance, whereas the heritability of bone microstructure is not clearly established. aBMD and microstructure are under the control of osteocytes, which regulate bone formation through the expression of molecules such as sclerostin (SOST) and periostin (POSTN). OBJECTIVE: We hypothesized that additive genetic effects contribute...

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PMID: 25867813
DOI: 10.1210/jc.2015-1183

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