Article
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
Addiction biology - 1 Mar 2016
Clarke Toni-Kim, Smith Andrew H, Gelernter Joel, Kranzler Henry R, Farrer Lindsay A, Hall Lynsey S, Fernandez-Pujals Ana M, MacIntyre Donald J, Smith Blair H, Hocking Lynne J, Padmanabhan Sandosh, Hayward Caroline, Thomson Pippa A, Porteous David J, Deary Ian J, McIntosh Andrew M
Abstract excerpt
Alcohol dependence is frequently co-morbid with cognitive impairment. The relationship between these traits is complex as cognitive dysfunction may arise as a consequence of heavy drinking or exist prior to the onset of dependence. In the present study, we tested the genetic overlap between cognitive abilities and alcohol dependence using polygenic risk scores (PGRS). We created two independent PGRS derived from...
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