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Article

Association of LRP5, TCF7L2, and GCG variants and type 2 diabetes mellitus as well as fasting plasma glucose and lipid metabolism indexes.

Human immunology - 1 May 2015

Wang Jinjin, Yan Guoli, Zhang Jianfeng, Gao Kaiping, Zhang Ming, Li Linlin, Wang Yan, Wang Qian, Zhai Yujia, You Haifei, Ren Yongcheng, Wang Bingyuan, Hu Dongsheng

Abstract excerpt

Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-regulated glucagon (GCG). Our previous studies suggest that the WNT signaling pathway plays a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25863010
DOI: 10.1016/j.humimm.2015.03.005

Genes

LRP5
GCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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