Article
DAT1 methylation changes in alcohol-dependent individuals vs. controls.
Journal of psychiatric research - 1 May 2015
Jasiewicz Andrzej, Rubiś Błażej, Samochowiec Jerzy, Małecka Iwona, Suchanecka Aleksandra, Jabłoński Marcin, Grzywacz Anna
Abstract excerpt
INTRODUCTION: The dopaminergic system plays a crucial role in the development of alcohol dependence. Regulation of the extracellular dopamine concentration is driven by dopamine transporter. Both, the expression and function of dopamine transporter, are influenced by chronic alcohol intake. Dopamine transporter (DAT) gene is also supposed to be differentially methylated in alcohol-dependent patients than in...
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