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Article

Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.

International journal of cancer - 15 Jan 2012

Castro Felipe A, Ivansson Emma L, Schmitt Markus, Juko-Pecirep Ivana, Kjellberg Lennart, Hildesheim Allan, Gyllensten Ulf B, Pawlita Michael

Abstract excerpt

Cervical cancer (CxCa) is caused by persistent human papillomavirus (HPV) infection; genetic predisposition is also suspected to play a role. Our study is a targeted candidate gene follow-up based on: (i) strong clinical evidence demonstrating that mutations in the TMC6 and TMC8 (EVER1 and EVER2) genes associate with the HPV-associated disease epidermodysplasia verruciformis (EV) and (ii) recent epidemiological...

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Source

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Identifiers

PMID: 21387292
DOI: 10.1002/ijc.26016
PMCID: PMC3530613

Genes

TMC6
TMC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.PMID 21387292Read ↗

A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.Semantic proximity Read ↗

Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study.Semantic proximity Read ↗

Homozygosity for the c.917A→T (p.N306l) polymorphism in the EVER2/TMC8 gene of two sisters with epidermodysplasia verruciformis Lewandowsky-Lutz originally described by Wilhelm Lutz.Semantic proximity Read ↗

Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.Semantic proximity Read ↗

Epidermodysplasia verruciformis in a HIV-positive patient homozygous for the c917A-->T polymorphism in the TMC8/EVER2 gene.Semantic proximity Read ↗

Four mutations in Epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRP.Semantic proximity Read ↗

Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.Semantic proximity Read ↗

The human CIB1–EVER1–EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomavirusesSemantic proximity Read ↗

Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformisSemantic proximity Read ↗

Identification of LCK mutation in a family with atypical epidermodysplasia verruciformis with T-cell defects and virus-induced squamous cell carcinoma.Semantic proximity Read ↗

Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation.Semantic proximity Read ↗

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