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Article

Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Polley Shamik, Louzada Sandra, Forni Diego, Sironi Manuela, Balaskas Theodosius, Hains David S, Yang Fengtang, Hollox Edward J

Abstract excerpt

The dietary change resulting from the domestication of plant and animal species and development of agriculture at different locations across the world was one of the most significant changes in human evolution. An increase in dietary carbohydrates caused an increase in dental caries following the development of agriculture, mediated by the cariogenic oral bacterium Streptococcus mutans. Salivary agglutinin [SAG,...

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Source

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Identifiers

PMID: 25848046
DOI: 10.1073/pnas.1416531112
PMCID: PMC4413317

Genes

DMBT1
SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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