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Rgg protein structure–function and inhibition by cyclic peptide compounds

6 Apr 2015

Abstract excerpt

Peptide pheromone cell-cell signaling (quorum sensing) regulates the expression of diverse developmental phenotypes (including virulence) in Firmicutes, which includes common human pathogens, e.g., Streptococcus pyogenes and Streptococcus pneumoniae. Cytoplasmic transcription factors known as "Rgg proteins" are peptide pheromone receptors ubiquitous in Firmicutes. Here we present X-ray crystal structures of a...

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PMID: 25847993
DOI: 10.1073/pnas.1500357112

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