Article
Multiple length peptide-pheromone variants produced by Streptococcus pyogenes directly bind Rgg proteins to confer transcriptional regulation.
The Journal of biological chemistry - 8 Aug 2014
Aggarwal Chaitanya, Jimenez Juan Cristobal, Nanavati Dhaval, Federle Michael J
Abstract excerpt
Streptococcus pyogenes, a human-restricted pathogen, accounts for substantial mortality related to infections worldwide. Recent studies indicate that streptococci produce and respond to several secreted peptide signaling molecules (pheromones), including those known as short hydrophobic peptides (SHPs), to regulate gene expression by a quorum-sensing mechanism. Upon transport into the bacterial cell, pheromones...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Genetic Variation
- Humans
- Pheromones
- Protein Binding
- Quorum Sensing
- Streptococcus pyogenes
- Trans-Activators