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Genome-Wide DNA Methylation Modified by Soy Phytoestrogens: Role for Epigenetic Therapeutics in Prostate Cancer?

1 Apr 2015

Abstract excerpt

In prostate cancer, DNA methylation is significantly associated with tumor initiation, progression, and metastasis. Previous studies have suggested that soy phytoestrogens might regulate DNA methylation at individual candidate gene loci and that they play a crucial role as potential therapeutic agents for prostate cancer. The purpose of our study was to examine the modulation effects of phytoestrogens on a...

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PMID: 25831061
DOI: 10.1089/omi.2014.0142

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