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Article

Genistein depletes telomerase activity through cross‐talk between genetic and epigenetic mechanisms

27 Feb 2009

Abstract excerpt

Genistein, a natural isoflavone found in soybean products, has been reported to down-regulate telomerase activity and that this prevents cancer and contributes to the apoptosis of cancer cells. However, the precise molecular mechanism by which genistein represses telomerase is not clear. Here, we show that genistein inhibits the transcription of hTERT (human telomerase reverse transcriptase), the catalytic...

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PMID: 19358274
DOI: 10.1002/ijc.24398

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