Article
Epidermolysis bullosa simplex generalized severe induces a T helper 17 response and is improved by apremilast treatment.
The British journal of dermatology - 1 Feb 2019
Castela E, Tulic M K, Rozières A, Bourrat E, Nicolas J-F, Kanitakis J, Vabres P, Bessis D, Mazereeuw J, Morice-Picard F, Baty D, Berard F, Lacour J-P, Passeron T, Chiaverini C
Abstract excerpt
BACKGROUND: Epidermolysis bullosa simplex generalized severe (EBS-gen sev) is a genetic disorder caused by mutation in the KRT5 or KRT14 genes. Although it is usually considered a mechanical disease, recent data argue for additional inflammatory mechanisms. OBJECTIVES: To assess the inflammation in the skin of patients with EBS-gen sev. METHODS: A first immunohistochemical retrospective study was performed on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.