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Article

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Circulation research - 8 May 2015

Roukens M Guy, Peterson-Maduro Josi, Padberg Yvonne, Jeltsch Michael, Leppänen Veli-Matti, Bos Frank L, Alitalo Kari, Schulte-Merker Stefan, Schulte Dörte

Abstract excerpt

RATIONALE: Collagen- and calcium-binding EGF domain-containing protein 1 (CCBE1) is essential for lymphangiogenesis in vertebrates and has been associated with Hennekam syndrome. Recently, CCBE1 has emerged as a crucial regulator of vascular endothelial growth factor-C (VEGFC) signaling. OBJECTIV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25814692
DOI: 10.1161/CIRCRESAHA.116.304949

Genes

CCBE1
EGF
VEGFC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25814692-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.PMID 25814692Read ↗

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Atypical E2fs Control Lymphangiogenesis through Transcriptional Regulation of Ccbe1 and Flt4Semantic proximity Read ↗

CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphaticsSemantic proximity Read ↗

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