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Article

Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation.

Experimental & molecular medicine - 27 Mar 2015

Bae Eun-Jin, Yang Na Young, Lee Cheolsoon, Lee He-Jin, Kim Seokjoong, Sardi Sergio Pablo, Lee Seung-Jae

Abstract excerpt

Lysosomal dysfunction is a common pathological feature of neurodegenerative diseases. GTP-binding protein type A1 (GBA1) encodes β-glucocerebrosidase 1 (GCase 1), a lysosomal hydrolase. Homozygous mutations in GBA1 cause Gaucher disease, the most common lysosomal storage disease, while heterozygous mutations are strong risk factors for Parkinson's disease. However, whether loss of GCase 1 activity is sufficient...

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Source

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Identifiers

PMID: 25813221
DOI: 10.1038/emm.2014.128
PMCID: PMC4351412

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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