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Article

MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Mar 2015

Messéant Julien, Dobbertin Alexandre, Girard Emmanuelle, Delers Perrine, Manuel Marin, Mangione Francesca, Schmitt Alain, Le Denmat Dominique, Molgó Jordi, Zytnicki Daniel, Schaeffer Laurent, Legay Claire, Strochlic Laure

Abstract excerpt

The muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ) formation. MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-rich domain [CRD]). Dysfunction of MuSK CRD in patients has been recently associated with the onset of myasthenia, common neuromuscular disorders mainly characterized by fatigable muscle weakness. However, the...

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Identifiers

PMID: 25810523
DOI: 10.1523/JNEUROSCI.3381-14.2015
PMCID: PMC6705368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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